Trifluoroacetic acid → HCID 59463765, compound

HRID 908533Notes

Reaction equation

HRID 908533 reaction equation
C(O)(C(F)(F)F)=O.C(OC(=O)[NH:14][CH2:15][CH:16]([CH2:27][O:28][C:29]([C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1)([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[CH2:17][CH2:18][N:19]1[CH:24]=[CH:23][C:22](=[O:25])[NH:21][C:20]1=[O:26])(C)(C)C>ClCCl>[NH2:14][CH2:15][CH:16]([CH2:27][O:28][C:29]([C:42]1[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=1)([C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1)[C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1)[CH2:17][CH2:18][N:19]1[CH:24]=[CH:23][C:22](=[O:25])[NH:21][C:20]1=[O:26]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59463762HCID 59463762, compound

Product 1

HCID 59463765HCID 59463765, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

TFA (2 ml) was added to a solution of compound 42 (100 mg, 0.18 mmol) in dichloromethane (4 ml) and the solution was stirred at room temperature. After 30 min the solvents were evaporated in vacuo and the afforded residue was purified by column chromatography on silica gel which gave the title compound (52 mg, 65%).

Workup

  1. customAfter 30 min the solvents were evaporated in vacuo
  2. customthe afforded residue was purified by column chromatography on silica gel which

Sources & evidence

ORD record
ord-6614962b560742cbb904a1d95279d8ee
Source dataset
uspto-grants-2011_09
Patent number
US08017620B2

Reaction notes

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