Water → HCID 59340050, compound

HRID 908552Notes

Reaction equation

HRID 908552 reaction equation
[H-].[Na+].[C:3]([O:10][CH3:11])(=[O:9])[CH2:4][C:5](OC)=[O:6].[Br:12][C:13]1[CH:14]=[CH:15][C:16]2[C:21](=O)[O:20][C:19](=O)[N:18](C)[C:17]=2[CH:25]=1.O>CN(C=O)C>[Br:12][C:13]1[CH:25]=[C:17]2[C:16]([C:21]([OH:20])=[C:4]([C:3]([O:10][CH3:11])=[O:9])[C:5](=[O:6])[N:18]2[CH3:19])=[CH:15][CH:14]=1

Participants

6

Reactant 4

HCID 962WaterHCID 7943Dimethyl malonateHCID 24758Sodium hydrideHCID 59340108HCID 59340108, compound

Product 1

HCID 59340050HCID 59340050, compoundYield 67.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

To a 50 mL RBF was added sodium hydride (0.15 g, 3.7 mmol) and N,N-dimethylformamide (50 mL, 3.1 mmol) under nitrogen. The mixture was cooled with an ice-water bath for 10 min, and then dimethyl malonate (6.4 mL, 56 mmol) was added over 3 min. A mixture of 7-bromo-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione (0.80 g, 3.1 mmol) in DMF (5.0 mL) was added, and then the reaction was placed in oil bath at 120° C. for 3 hours. The reaction was cooled to room temperature, and water (25 mL) was added to the mixture. A white solid was collected by filtration and washed with water (100 mL), followed by ether (100 mL). The white solid was placed in vacuum oven at 50° C. for 6 h to afford the desired product as a white solid (0.65 g, 67%).

Workup

  1. temperatureThe mixture was cooled with an ice-water bath for 10 min
  2. additionwas added
  3. filtrationA white solid was collected by filtration
  4. washwashed with water (100 mL)
  5. waitThe white solid was placed in vacuum oven at 50° C. for 6 h

Sources & evidence

ORD record
ord-c0273f428adc4107b9cbed7ba614e807
Source dataset
uspto-grants-2011_09
Patent number
US08017626B2

Reaction notes

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