反应详情

To a solution of the compound (973 mg) obtained in Step 2 in ethyl acetate (10 ml) was added, with stirring at room temperature, 4N hydrogen chloride/ethyl acetate solution (4.73 ml). After stirring at room temperature for 4 hr, the reaction mixture was concentrated under reduced pressure. Toluene was added to the residue, and the mixture was concentrated again under reduced pressure. The obtained crude crystals were suspended in a mixed solvent of ethyl acetate and diisopropyl ether, collected by filtration and dried to give the title compound (742 mg).

1. stirringAfter stirring at room temperature for 4 hr
2. concentrationthe reaction mixture was concentrated under reduced pressure
3. additionToluene was added to the residue
4. concentrationthe mixture was concentrated again under reduced pressure
5. customThe obtained crude crystals
6. filtrationcollected by filtration
7. customdried