反应详情

温度

60 °C

A mixture of the compound (61 mg) obtained in Example 1, 5-chloropyrazine-2-carboxylic acid methyl ester (25 mg) and triethylamine (42 μl) in N,N-dimethylformamide (0.3 ml) was stirred at 60° C. for 14 hr. The reaction mixture was concentrated under reduced pressure, and the residue was purified by thin layer chromatography (5% methanol/chloroform) to give the title compound (75 mg).

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. customthe residue was purified by thin layer chromatography (5% methanol/chloroform)