反应详情

To a solution of the compound (2.58 g) obtained in Step 3 in chloroform (26 ml) was added, with stirring at room temperature, triethylamine (896 μl), and 9-fluorenylmethoxycarbonyl isothiocyanate (1.66 g) was added. After stirring overnight at room temperature, piperidine (1.11 ml) was added. After stirring overnight at room temperature, the reaction mixture was concentrated under reduced pressure, and purified by column chromatography (5% methanol/chloroform) to give the title compound (2.12 g).

1. stirringAfter stirring overnight at room temperature
2. stirringAfter stirring overnight at room temperature
3. concentrationthe reaction mixture was concentrated under reduced pressure
4. custompurified by column chromatography (5% methanol/chloroform)