Water → HCID 178508244, compound

HRID 908607Notes

Reaction equation

HRID 908607 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([CH:8]2[CH2:10][CH2:9]2)[N:5]=[C:4]([OH:11])[C:3]=1[S:12][C:13]#[N:14].O>CN(C)C=O>[NH2:14][C:13]1[S:12][C:3]2[C:4]([OH:11])=[N:5][C:6]([CH:8]3[CH2:10][CH2:9]3)=[N:7][C:2]=2[N:1]=1

Participants

4

Reactant 2

HCID 962WaterHCID 178514141HCID 178514141, compound

Product 1

HCID 178508244HCID 178508244, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
135 °C

Procedure

A solution of the compound (0.20 g) obtained in Step 2 in N,N-dimethylformamide (7.0 ml) was stirred overnight under heating at 135° C. The reaction mixture was cooled to room temperature, and water (7.0 ml) was added under ice-cooling. The precipitated solid was collected by filtration, washed with water and dried to give the title compound (0.15 g).

Workup

  1. temperatureThe reaction mixture was cooled to room temperature
  2. temperaturecooling
  3. filtrationThe precipitated solid was collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-e13312c5756144e7accf0d7320a633ae
Source dataset
uspto-grants-2011_09
Patent number
US08017612B2

Reaction notes

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