反应详情

To a mixed solution of the compound (26 mg) obtained in Example 783, the compound (10 mg) obtained in Step 6 and isopropanol (1.0 ml) was added triethylamine (14 μl) at room temperature, and the mixture was heated under reflux overnight. The reaction mixture was concentrated under reduced pressure, and the residue was purified by thin layer silica gel chromatography (methanol:chloroform=1:20, developed twice) to give the title compound (31 mg).

1. temperaturethe mixture was heated
2. temperatureunder reflux overnight
3. concentrationThe reaction mixture was concentrated under reduced pressure
4. customthe residue was purified by thin layer silica gel chromatography (methanol