反应详情

To a mixture of the compound (87 mg) obtained in Example 983, Step 2 and the compound (32 mg) obtained in Step 5 in isopropanol (0.9 ml) was added N,N-diisopropylethylamine (30 μl) at room temperature. After stirring overnight at room temperature, and the mixture was stirred with heating under reflux for 5 hr. The reaction mixture was concentrated under reduced pressure, and the residue was purified by thin layer silica gel chromatography (methanol:chloroform=5:95) to give the title compound (84 mg).

1. stirringthe mixture was stirred
2. temperaturewith heating
3. temperatureunder reflux for 5 hr
4. concentrationThe reaction mixture was concentrated under reduced pressure
5. customthe residue was purified by thin layer silica gel chromatography (methanol:chloroform=5:95)