反应详情

To a solution of the compound (40 mg) obtained in Step 6 in THF (0.8 ml) were added methanol (3.7 μl), triphenylphosphine (24 mg) and diisopropyl azodicarboxylate (18 μl) with stirring under ice-cooling, and the mixture was stirred overnight at room temperature. Methanol (1.2 μl), triphenylphosphine (8 mg) and diisopropyl azodicarboxylate (6 μl) was added at room temperature, and the mixture was stirred for 3 hr. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (methanol:chloroform=5:95) to give the title compound (29 mg).

1. temperaturecooling
2. stirringthe mixture was stirred overnight at room temperature
3. stirringthe mixture was stirred for 3 hr
4. concentrationThe reaction mixture was concentrated under reduced pressure
5. customthe residue was purified by silica gel column chromatography (methanol:chloroform=5:95)