Triethylamine → 3-(Naphthalen-2-yl)propyl methanesulfonate

HRID 908898Notes

Reaction equation

HRID 908898 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][CH2:12][CH2:13][OH:14].C(N(CC)CC)C.[CH3:22][S:23](Cl)(=[O:25])=[O:24]>ClCCl>[S:23]([O:14][CH2:13][CH2:12][CH2:11][C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:1]=1)(=[O:25])(=[O:24])[CH3:22]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 112062322-Naphthalenepropanol

Product 1

HCID 111613853-(Naphthalen-2-yl)propyl methanesulfonate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Following the procedure described in example 1§B, but starting from 3-(2-naphtyl)propan-1-ol (11.7 mmol), triethylamine (2.5 mL), methanesulfonyl chloride (1.7 mL) and dichloromethane (50 mL), affords 1.7 g of 3-(2-naphtyl)propan-1-ol mesylate used without further purification.

Sources & evidence

ORD record
ord-1213e379f0bf45dab0f2e217c0f3cb93
Source dataset
uspto-grants-2011_09
Patent number
US08017646B2

Reaction notes

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