反应详情

To a mixture of 2-(piperidin-4-yl)-acetic acid ethyl ester (211.4 mg, 1.234 mmol, Oakwood,) in N,N-dimethyl formamide (5.0 mL) was added 1,1′-carbonyldiimidazole (216 mg, 1.332 mmol Aldrich). After it was stirred at rt for 4 days under an argon atmosphere, the solvent was removed and the reaction mixture was extracted with EtOAc, and washed with water (2×), and saturated NaCl. The organic phase was separated, dried over Na2SO4, filtered and concentrated to give [1-(imidazole-1-carbonyl)-piperidin-4-yl]acetic acid ethyl ester (293.3 mg, 1.10 mmol, 89.6%) which was used without further purification.

1. customthe solvent was removed
2. extractionthe reaction mixture was extracted with EtOAc
3. washwashed with water (2×), and saturated NaCl
4. customThe organic phase was separated
5. dry with materialdried over Na2SO4
6. filtrationfiltered
7. concentrationconcentrated