反应详情

To a solution of 3-Bromo-5-chlorosulfonyl-4-fluoro-benzoic acid (3.0 g) in dioxane/water (9/1 (v/v), 30 ml) was added DiPEA (5 ml) and morpholine (1.65 ml). After stirring for 2 h, the mixture was diluted with EtOAc and washed with 2 M aq. HCl. The organic layer was dried (Na2SO4) and concentrated in vacuo. Yield: 2.6 g.

1. washwashed with 2 M aq. HCl
2. dry with materialThe organic layer was dried (Na2SO4)
3. concentrationconcentrated in vacuo