反应详情

Then, Et3SiH (9.2 mL, 0.058 mol) and BF3.Et2O (3.6 mL, 0.029 mol) were added sequentially to a chloroform (110 mL) solution of (1-benzothien-2-yl)(5-bromo-2-chlorophenyl)methanol (10.2 g, 0.0288 mol) at −15° C. The reaction mixture was warmed to room temperature and stirred at the temperature for ten hours. After the reaction mixture was added with a saturated sodium bicarbonate aqueous solution, the organic phase was separated, washed with brine and then dried with anhydrous magnesium sulfate. After the desiccant was filtered off, the residue obtained by evaporating the solvent under reduced pressure was purified by silica gel column chromatography (hexane:ethyl acetate=60:1) to obtain a colorless oily title compound (5.5 g, 56%).

1. customthe organic phase was separated
2. washwashed with brine
3. dry with materialdried with anhydrous magnesium sulfate
4. filtrationAfter the desiccant was filtered off
5. customthe residue obtained
6. customby evaporating the solvent under reduced pressure
7. customwas purified by silica gel column chromatography (hexane:ethyl acetate=60:1)