Water → HCID 67405072, compound

HRID 910208Notes

Reaction equation

HRID 910208 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([I:8])=[CH:4][N:3]=1.Br[CH2:10][C:11]([C:13]1[CH:18]=[CH:17][C:16]([C:19]#[N:20])=[CH:15][CH:14]=1)=O.C(=O)([O-])O.[Na+].O>C(O)C>[I:8][C:5]1[CH:6]=[CH:7][C:2]2[N:3]([CH:10]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([C:19]#[N:20])=[CH:15][CH:14]=3)[N:1]=2)[CH:4]=1

Participants

6

Reactant 4

HCID 962WaterHCID 885792-Pyridinamine, 5-iodo-HCID 986544-(Bromoacetyl)benzonitrileHCID 516892Sodium Bicarbonate

Product 1

HCID 67405072HCID 67405072, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-Amino-5-iodopyridine (1.0 g) and 2-bromo-4′-cyanoacetophenone (1.02 g) were dissolved in ethanol (30 mL), and sodium hydrogencarbonate (382 mg) was added to the solution, followed by refluxing for 16 hours. Water (10 mL) was added to the reaction mixture, and the mixture was left to cool. The precipitated matter was recovered through filtration and dried, to thereby yield the title compound (1.27 g).

Workup

  1. temperatureby refluxing for 16 hours
  2. waitthe mixture was left
  3. temperatureto cool
  4. filtrationThe precipitated matter was recovered through filtration
  5. customdried

Sources & evidence

ORD record
ord-9892104ffcf244ad8effa9d5568bc547
Source dataset
uspto-grants-2011_09
Patent number
US08022075B2

Reaction notes

Loading…