Potassium Carbonate → HCID 16735616, compound

HRID 910210Notes

Reaction equation

HRID 910210 reaction equation
[I:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]3[CH:18]=[CH:17][C:14]([CH:15]=[O:16])=[CH:13][CH:12]=3)[N:10]=2)[CH:7]=1.C1(C)C=CC(S([CH2:28][N+:29]#[C-:30])(=O)=O)=CC=1.C(=O)([O-])[O-].[K+].[K+]>CO>[I:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]3[CH:18]=[CH:17][C:14]([C:15]4[O:16][CH:30]=[N:29][CH:28]=4)=[CH:13][CH:12]=3)[N:10]=2)[CH:7]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 161915Tosylmethyl isocyanideHCID 16738347HCID 16738347, compound

Product 1

HCID 16735616HCID 16735616, compoundYield 45.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-(6-Iodoimidazo[1,2-a]pyridin-2-yl)benzaldehyde (647 mg) and p-toluenesulfonylmethyl isocyanide (454 mg) were dissolved in methanol (10 mL), and potassium carbonate (321 mg) was added to the solution at room temperature, followed by refluxing for 13 hours. The precipitated product was recovered through filtration and dried, to thereby yield the title compound (330 mg).

Workup

  1. temperatureby refluxing for 13 hours
  2. filtrationThe precipitated product was recovered through filtration
  3. customdried

Sources & evidence

ORD record
ord-566a10d1a880433c8a2abb72a75aa68c
Source dataset
uspto-grants-2011_09
Patent number
US08022075B2

Reaction notes

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