Hydroxyamine hydrochloride → HCID 67403932, compound

HRID 910219Notes

Reaction equation

HRID 910219 reaction equation
Cl.NO.C[N:5](C)/[CH:6]=[CH:7]/[C:8]([C:10]1[CH:15]=[CH:14][C:13]([C:16]2[N:17]=[C:18]3[CH:23]=[CH:22][C:21]([I:24])=[CH:20][N:19]3[CH:25]=2)=[CH:12][CH:11]=1)=[O:9]>C(O)C>[I:24][C:21]1[CH:22]=[CH:23][C:18]2[N:19]([CH:25]=[C:16]([C:13]3[CH:14]=[CH:15][C:10]([C:8]4[O:9][N:5]=[CH:6][CH:7]=4)=[CH:11][CH:12]=3)[N:17]=2)[CH:20]=1

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 16735150HCID 16735150, compound

Product 1

HCID 67403932HCID 67403932, compoundYield 24.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Hydroxylamine hydrochloride (53 mg) was added to a solution (5 mL) of (E)-3-(dimethylamino)-1-[4-(6-iodoimidazo[1,2-a]pyridin-2-yl)phenyl]-2-propen-1-one (104 mg) in ethanol, followed by refluxing for 2 hours. The solvent was evaporated, and the residue was purified through silica gel chromatography (dichloromethane:methanol=97:3), to thereby yield the title compound (24 mg).

Workup

  1. temperatureby refluxing for 2 hours
  2. customThe solvent was evaporated
  3. customthe residue was purified through silica gel chromatography (dichloromethane:methanol=97:3)

Sources & evidence

ORD record
ord-b7f07d3e33e14cdc8bc8b21e53276d70
Source dataset
uspto-grants-2011_09
Patent number
US08022075B2

Reaction notes

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