2-Amino-5-chloropyridine → 5-[4-(6-Chloroimidazo[1,2-a]pyridin-2-yl)phenyl]-1,3-oxazole

HRID 910225Notes

Reaction equation

HRID 910225 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=1.Br[CH2:10][C:11]([C:13]1[CH:18]=[CH:17][C:16]([C:19]2[O:23][CH:22]=[N:21][CH:20]=2)=[CH:15][CH:14]=1)=O>>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]2[N:3]([CH:10]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([C:19]4[O:23][CH:22]=[N:21][CH:20]=4)=[CH:15][CH:14]=3)[N:1]=2)[CH:4]=1

Participants

3

Reactant 2

HCID 661742-Amino-5-chloropyridineHCID 866318862-Bromo-1-[4-(1,3-oxazol-5-yl)phenyl]-1-ethanone

Product 1

HCID 252041195-[4-(6-Chloroimidazo[1,2-a]pyridin-2-yl)phenyl]-1,3-oxazoleYield 27%

Procedure

The procedure of Referential Example 1 was repeated, except that 2-amino-5-chloropyridine (49 mg) and 2-bromo-1-[4-(1,3-oxazol-5-yl)phenyl]-1-ethanone (100 mg), which had been produced in Referential Example 10 were used, to thereby yield the title compound (30 mg).

Workup

  1. customhad been produced in Referential Example 10

Sources & evidence

ORD record
ord-3fcb4a2578e24390a13189413608667a
Source dataset
uspto-grants-2011_09
Patent number
US08022075B2

Reaction notes

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