Methyl 4-Formylbenzoate → Methyl 4-(1,3-oxazol-5-yl)benzoate

HRID 910230Notes

Reaction equation

HRID 910230 reaction equation
[CH:1]([C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][CH:4]=1)=[O:2].C1(C)C=CC(S([CH2:22][N:23]=[C:24]=O)(=O)=O)=CC=1>>[O:2]1[C:1]([C:3]2[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][CH:4]=2)=[CH:24][N:23]=[CH:22]1

Participants

3

Reactant 2

HCID 15294Methyl 4-FormylbenzoateHCID 117890781-Isocyanatomethanesulfonyl-4-methylbenzene

Product 1

HCID 1477779Methyl 4-(1,3-oxazol-5-yl)benzoateYield 86.7%

Procedure

The procedure of Example 1 was repeated, except that methyl 4-formylbenzoate (4.92 g) and p-toluenesulfonylmethylisocyanate (7.03 g) were used, to thereby yield the title compound (5.28 g).

Sources & evidence

ORD record
ord-8b746ed38abb4c5aba397f34fb336806
Source dataset
uspto-grants-2011_09
Patent number
US08022075B2

Reaction notes

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