2-Pyridinamine, 5-iodo- → HCID 67404368, compound

HRID 910242Notes

Reaction equation

HRID 910242 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([I:8])=[CH:4][N:3]=1.Br[CH2:10][C:11]([C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:20]=[N:21][N:22](C(OC(C)(C)C)=O)[CH:23]=2)=[CH:15][CH:14]=1)=O.C(=O)([O-])O.[Na+]>C(O)C>[I:8][C:5]1[CH:6]=[CH:7][C:2]2[N:3]([CH:10]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([C:19]4[CH:23]=[N:22][NH:21][CH:20]=4)=[CH:15][CH:14]=3)[N:1]=2)[CH:4]=1

Participants

5

Reactant 3

HCID 885792-Pyridinamine, 5-iodo-HCID 516892Sodium BicarbonateHCID 86761410HCID 86761410, compound

Product 1

HCID 67404368HCID 67404368, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Subsequently, 2-amino-5-iodopyridine (478 mg) and tert-butyl 4-[4-(2-bromoacetyl)phenyl]-1H-1-pyrazolecarboxylate mg) were dissolved in ethanol (20 mL), and sodium hydrogencarbonate (183 mg) was added to the solution, followed by refluxing for 16 hours. The precipitated matter was recovered through filtration and dried, to thereby yield the title compound (535 mg).

Workup

  1. temperatureby refluxing for 16 hours
  2. filtrationThe precipitated matter was recovered through filtration
  3. customdried

Sources & evidence

ORD record
ord-e5d440f8ce4e4ff68bbc7347f28c4e14
Source dataset
uspto-grants-2011_09
Patent number
US08022075B2

Reaction notes

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