Cyanuric chloride → HCID 11045887, compound

HRID 910665Notes

Reaction equation

HRID 910665 reaction equation
[N:1]1[C:8]([Cl:9])=[N:7][C:5]([Cl:6])=[N:4][C:2]=1Cl.[C:10]([N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1)([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11].C([O-])(O)=O.[Na+]>CC(C)=O.O>[C:13]([O:12][C:10]([N:17]1[CH2:22][CH2:21][N:20]([C:2]2[N:1]=[C:8]([Cl:9])[N:7]=[C:5]([Cl:6])[N:4]=2)[CH2:19][CH2:18]1)=[O:11])([CH3:16])([CH3:14])[CH3:15]

Participants

6

Reactant 3

HCID 7954Cyanuric chlorideHCID 143452tert-Butyl piperazine-1-carboxylateHCID 516892Sodium Bicarbonate

Product 1

HCID 11045887HCID 11045887, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolvent2×HCID 962WaterSolvent

Conditions

Temperature
0 °C

Procedure

Cyanuric chloride (2.22 g, 12.0 mmol) in acetone (50 mL) was added to well-stirred ice water (72 mL). To the resulting fine slurry at 0° C. was slowly added a solution of 1-Boc-piperazine (2.24 g, 12.0 mmol) in acetone (20 mL). A solution of NaHCO3 (1.0 g) in water (20 mL) was slowly added to the mixture, which was subsequently stirred at 0° C. for an additional 2.5 h. The resulting precipitate was collected by filtration, washed with water, and dried to yield a white solid, which was used without further purification.

Workup

  1. filtrationThe resulting precipitate was collected by filtration
  2. washwashed with water
  3. customdried
  4. customto yield a white solid, which
  5. customwas used without further purification

Sources & evidence

ORD record
ord-6ddfa109be894c768d5294ea7b72d2c2
Source dataset
uspto-grants-2011_09
Patent number
US08022209B2

Reaction notes

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