反应详情

温度

160 °C

To a microwave tube was added 2-chloro-4-thiophen-2-yl-pyrimidine (20 mg, 0.1 mmol), piperazine (26 mg, 0.3 mmol) and 2-propanol (0.6 mL). The resulting mixture was heated at 160° C. for 60 minutes using the microwave instrument. The resulting mixture was extracted with EtOAc. The organic layer was dried and concentrated, and the residue was purified by preparative TLC (hexanes/EtOAc) to yield the title compound as a solid.

1. extractionThe resulting mixture was extracted with EtOAc
2. customThe organic layer was dried
3. concentrationconcentrated
4. customthe residue was purified by preparative TLC (hexanes/EtOAc)