Piperazine → 2-Piperazin-1-yl-4-thiophen-2-yl-pyrimidine

HRID 910689Notes

Reaction equation

Cl[C:2]1[N:7]=[C:6]([C:8]2[S:9][CH:10]=[CH:11][CH:12]=2)[CH:5]=[CH:4][N:3]=1.[NH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>CC(O)C>[N:13]1([C:2]2[N:7]=[C:6]([C:8]3[S:9][CH:10]=[CH:11][CH:12]=3)[CH:5]=[CH:4][N:3]=2)[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1

Participants

Conditions

Temperature: 160 °C

Procedure

To a microwave tube was added 2-chloro-4-thiophen-2-yl-pyrimidine (20 mg, 0.1 mmol), piperazine (26 mg, 0.3 mmol) and 2-propanol (0.6 mL). The resulting mixture was heated at 160° C. for 60 minutes using the microwave instrument. The resulting mixture was extracted with EtOAc. The organic layer was dried and concentrated, and the residue was purified by preparative TLC (hexanes/EtOAc) to yield the title compound as a solid.

Workup

extractionThe resulting mixture was extracted with EtOAc
customThe organic layer was dried
concentrationconcentrated
customthe residue was purified by preparative TLC (hexanes/EtOAc)

Sources & evidence

ORD record: ord-ffc125d27a11461190d69eedfd15f499
Source dataset: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08022209B2

Reaction notes

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