Hydrochloric Acid → (+/-)-6-({[(1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one

HRID 91075Notes

Reaction equation

HRID 91075 reaction equation
[BH4-:45].[CH3:38][CH2:39][N:40]([CH2:41][CH3:42])[CH2:43][CH3:44].[CH3:50][CH2:51][OH:52].[Cl:47][CH2:48][Cl:49].[ClH:1].[NH2:2][CH2:3][C:4]1([OH:24])[CH2:5][N:6]([CH2:9][CH2:10][c:11]2[c:12]([F:23])[cH:13][n:14][c:15]3[cH:16][cH:17][c:18]([O:21][CH3:22])[n:19][c:20]23)[CH2:7][CH2:8]1.[Na+:46].[O:25]=[C:26]1[CH2:27][S:28][c:29]2[c:30]([n:32][c:33]([CH:36]=[O:37])[cH:34][cH:35]2)[NH:31]1>>[NH:2]([CH2:3][C:4]1([OH:24])[CH2:5][N:6]([CH2:9][CH2:10][c:11]2[c:12]([F:23])[cH:13][n:14][c:15]3[cH:16][cH:17][c:18]([O:21][CH3:22])[n:19][c:20]23)[CH2:7][CH2:8]1)[CH2:36][c:33]1[n:32][c:30]2[c:29]([cH:35][cH:34]1)[S:28][CH2:27][C:26](=[O:25])[NH:31]2

Participants

9

Reactant 8

HCID 313Hydrochloric AcidHCID 702EthanolHCID 923Sodium ionHCID 6344DichloromethaneHCID 8471TriethylamineHCID 28123BorohydrideHCID 115935913-Oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carbaldehydeHCID 685767703-(Aminomethyl)-1-[2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethyl]pyrrolidin-3-ol

Product 1

HCID 11634694(+/-)-6-({[(1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one

Sources & evidence

ORD record
ord-accc98a084914b58b049ff0c48c31073
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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