反应详情

温度

0 °C

At 0° C., 4-methyl-benzenesulfonyl chloride (3.8 g) was added to a solution of 2-propanol (6.12 ml) in pyridine (6.6 ml). The reaction mixture was stirred at 0° C. for 2 h and then at 20° C. for 16 h. The reaction mixture was poured into water (150 ml) and extracted with dichloromethane. The combined organic phases were washed with 3M aqueous HCl and sat. NaHCO3. After drying (MgSO4) and concentrating in vacuo, the title product was obtained as a pale yellow oil. Yield: 2.89 g. MS-ESI: [M+H]+=215.

1. waitat 20° C. for 16 h
2. extractionextracted with dichloromethane
3. washThe combined organic phases were washed with 3M aqueous HCl and sat. NaHCO3
4. dry with materialAfter drying (MgSO4)
5. concentrationconcentrating in vacuo