反应详情

Ethyl 4,5-dioxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate (1.56 g, 6.63 mmol) was dissolved in 20 mL of degassed N,N-dimethylformamide and treated with 4-bromobenzylbromide (1.99 g, 7.96 mmol) and potassium carbonate (1.10 g, 7.96 mmol). The mixture was stirred at ambient temperature for 18 hrs, and then partitioned between water and ethyl acetate. The aqueous layer was extracted twice with ethyl acetate and the combined ethyl acetate extracts were washed with water and brine, dried over sodium sulfate, filtered and concentrated in vacuo to provide ethyl 1-(4-bromobenzyl)-4,5-dioxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate.

1. custompartitioned between water and ethyl acetate
2. extractionThe aqueous layer was extracted twice with ethyl acetate
3. washthe combined ethyl acetate extracts were washed with water and brine
4. dry with materialdried over sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated in vacuo