Trifluoroacetic acid → HCID 67387632, compound

HRID 910786Notes

Reaction equation

HRID 910786 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].C(OC(=O)[NH:14][C@@H:15]([C:17]1[N:21]([CH2:22][CH3:23])[C:20]([S:24]([CH3:27])(=[O:26])=[O:25])=[N:19][N:18]=1)[CH3:16])(C)(C)C>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH2:22]([N:21]1[C:20]([S:24]([CH3:27])(=[O:26])=[O:25])=[N:19][N:18]=[C:17]1[C@H:15]([NH2:14])[CH3:16])[CH3:23]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58499943HCID 58499943, compound

Product 1

HCID 67387632HCID 67387632, compound

Procedure

Trifluoroacetic acid (121 ml) was added to the [(R)-1-(4-ethyl-5-methanesulfonyl-4H-[1,2,4]triazol-3-yl)ethyl]-carbamic acid t-butyl ester (100.0 g) obtained in Example 8-(5), and the mixture was stirred for 2 hours at room temperature. The reaction mixture was concentrated under reduced pressure to obtain (R)-1-(4-ethyl-5-methanesulfonyl-4H-[1,2,4]triazol-3-yl)ethylamine trifluoroacetate as a white powder (103.8 g).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-44c3aac4692044b6b1a09f4a9432b920
Source dataset
uspto-grants-2011_09
Patent number
US08022225B2

Reaction notes

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