反应详情

温度

55 °C

THP ether 39 (1.207 g, 3.03 mmol) was dissolved in 95% EtOH (12 ml) and PPTS (76 mg, 0.3 mmol) was added. Reaction mixture was stirred at 55° C. for 4 h, cooled to room temperature and diluted with EtOAc. Mixture was washed with H2O three times, organic extract was dried over Na2SO4 and evaporated. Residue was chromatographed on silica gel to give 864 mg (91%) of 17-acetoxy-heptadecanol.

1. customReaction mixture
2. temperaturecooled to room temperature
3. washMixture was washed with H2O three times
4. extractionorganic extract
5. dry with materialwas dried over Na2SO4
6. customevaporated
7. customResidue was chromatographed on silica gel