Triethylamine → HCID 86620100, compound

HRID 910825Notes

Reaction equation

HRID 910825 reaction equation
C(N(CC)CC)C.[CH3:8][S:9](Cl)(=[O:11])=[O:10].[OH:13][CH2:14][C:15]1[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][C:16]=1[O:17][C:18]1[CH:19]=[C:20]([CH:23]=[CH:24][CH:25]=1)[C:21]#[N:22]>C(Cl)Cl>[CH3:8][S:9]([O:13][CH2:14][C:15]1[CH:29]=[CH:28][C:27]([C:30]([F:31])([F:32])[F:33])=[CH:26][C:16]=1[O:17][C:18]1[CH:25]=[CH:24][CH:23]=[C:20]([C:21]#[N:22])[CH:19]=1)(=[O:11])=[O:10]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 67392158HCID 67392158, compound

Product 1

HCID 86620100HCID 86620100, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Conditions

Temperature
0 °C

Procedure

Triethylamine (0.33 ml) followed by methanesulphonyl chloride (0.185 ml) were added to a solution of the product from step (ii) (0.7 g) in DCM (20 ml) at −20° C. The mixture was stirred at 0° C. for 1 h, then diluted with dichloromethane, washed with water, dried and evaporated under reduced pressure, yield 0.97 g.

Workup

  1. washwashed with water
  2. customdried
  3. customevaporated under reduced pressure, yield 0.97 g

Sources & evidence

ORD record
ord-12c96d1b8b584a0fb70b46002f63775e
Source dataset
uspto-grants-2011_09
Patent number
US08022248B2

Reaction notes

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