Triethylamine → HCID 58882949, compound

HRID 910842Notes

Reaction equation

HRID 910842 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[CH2:16]O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CS([Cl:22])(=O)=O.C(N(CC)CC)C>C(Cl)Cl>[Cl:22][CH2:16][C:10]1[CH:11]=[CH:12][C:13]([F:15])=[CH:14][C:9]=1[O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 58882932(2-(Benzyloxy)-4-fluorophenyl)methanol

Product 1

HCID 58882949HCID 58882949, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of the product from step (iii) (1.06 g), methane sulphonyl chloride (0.351 ml) and triethylamine (0.636 ml) in DCM (20 ml) was stirred at RT for 2 h. The mixture was partitioned between water/DCM, the organics separated, dried and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with isohexane/DCM 1:1, yield 0.7 g.

Workup

  1. customThe mixture was partitioned between water/DCM
  2. customthe organics separated, dried
  3. customevaporated under reduced pressure
  4. customThe residue was purified by chromatography on silica eluting with isohexane/DCM 1:1, yield 0.7 g

Sources & evidence

ORD record
ord-a74d5abf1c9a4a3393bc13c0b7a2e9eb
Source dataset
uspto-grants-2011_09
Patent number
US08022248B2

Reaction notes

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