反应详情

A mixture of the product from step (iii) (1.06 g), methane sulphonyl chloride (0.351 ml) and triethylamine (0.636 ml) in DCM (20 ml) was stirred at RT for 2 h. The mixture was partitioned between water/DCM, the organics separated, dried and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with isohexane/DCM 1:1, yield 0.7 g.

1. customThe mixture was partitioned between water/DCM
2. customthe organics separated, dried
3. customevaporated under reduced pressure
4. customThe residue was purified by chromatography on silica eluting with isohexane/DCM 1:1, yield 0.7 g