反应详情

Using the method of Example 3, step B, 2-chloro-4-(2-methoxyphenoxy)pyridine (2.95 g, 12.5 mmol), 4-methylthiazol-2-amine (28.5 mL, 11.4 mmol), potassium phosphate (2.66 g, 12.5 mmol), Pd2(dba)3 (0.261 g, 0.285 mmol) and 4,5-bis(diphenylphosphino)-9,9-dimethyl-9H-xanthene (0.181 g, 0.313 mmol) were reacted in toluene (30 mL) and water (8 mL) to provide 4-(2-methoxyphenoxy)-N-(4-methylthiazol-2-yl)pyridin-2-amine (3.12 g, 82.2% yield) as yellow solid. 1H NMR (CDCl3) δ 8.10 (d, 1H), 7.19 (m, 1H), 7.04 (dd, 1H), 6.95 (m, 2H), 6.42 (dd, 1H), 6.24 (d, 1H), 6.14 (d, 1H), 3.71 (s, 1H), 2.12 (s, 3H); Mass spectrum (apci) m/z=314 (100) (4+H).