3-Chlorothiophenol → HCID 63779018, compound

HRID 910951Notes

Reaction equation

HRID 910951 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([SH:8])[CH:5]=[CH:6][CH:7]=1.[H-].[Na+].[Cl:11][C:12]1[CH:17]=[C:16]([N+]([O-])=O)[CH:15]=[CH:14][N:13]=1>>[Cl:11][C:12]1[CH:17]=[C:16]([S:8][C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)[CH:15]=[CH:14][N:13]=1

Participants

4

Reactant 3

HCID 162573-ChlorothiophenolHCID 24758Sodium hydrideHCID 7351522-Chloro-4-nitropyridine

Product 1

HCID 63779018HCID 63779018, compoundYield 92%

Procedure

Using the method of Example 3, Step A, 3-chlorobenzenethiol (912 mg, 6.31 mmol), 60% sodium hydride in mineral oil (252 mg, 6.31 mmol), and 2-chloro-4-nitropyridine (1.00 g, 6.31 mmol) were reacted to afford 2-chloro-4-(3-chlorophenylthio)pyridine (1.48 g, 92% yield) as an oil. 1H NMR (CDCl3) δ 8.16 (d, 1H), 7.56 (s, 1H), 7.39-7.49 (m, 3H), 6.94 (s, 1H), 6.88 (d, 1H).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-6eb1347876c743899d9fa637f959a140
Source dataset
uspto-grants-2011_09
Patent number
US08022222B2

Reaction notes

Loading…