2-Chlorophenol → HCID 63777947, compound

HRID 910972Notes

Reaction equation

HRID 910972 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].[H-].[Na+].[Cl:11][C:12]1[CH:17]=[C:16]([N+]([O-])=O)[CH:15]=[CH:14][N:13]=1>>[Cl:11][C:12]1[CH:17]=[C:16]([O:8][C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])[CH:15]=[CH:14][N:13]=1

Participants

4

Reactant 3

HCID 72452-ChlorophenolHCID 24758Sodium hydrideHCID 7351522-Chloro-4-nitropyridine

Product 1

HCID 63777947HCID 63777947, compoundYield 95%

Procedure

Using the method of Example 3, Step A, 2-chlorophenol (811 mg, 6.31 mmol), 60% sodium hydride in mineral oil (252 mg, 6.31 mmol), and 2-chloro-4-nitropyridine (1.00 g, 6.31 mmol) were reacted to provide 2-chloro-4-(2-chlorophenoxy)pyridine (0.98 g, 95% yield) as an oil. 1H NMR (CDCl3) δ 8.25 (d, 1H), 7.52 (d, 1H), 7.36 (t, 1H), 7.28 (t, 1H), 7.17 (d, 1H), 6.74-6.77 (m, 2H).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-4e60f66df0d445bb85b7af385e87909d
Source dataset
uspto-grants-2011_09
Patent number
US08022222B2

Reaction notes

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