Sodium hydride → HCID 86634732, compound

HRID 910982Notes

Reaction equation

HRID 910982 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[SH:9].[H-].[Na+].[Cl:14][C:15]1[CH:20]=[C:19]([N+]([O-])=O)[CH:18]=[CH:17][N:16]=1>>[Cl:14][C:15]1[CH:20]=[C:19]([S:9][C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[C:2]([F:1])([F:10])[F:11])[CH:18]=[CH:17][N:16]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 7351522-Chloro-4-nitropyridineHCID 27778892-(Trifluoromethyl)benzenethiol

Product 1

HCID 86634732HCID 86634732, compoundYield 93%

Procedure

Using the method of Example 3, Step A, 2-(trifluoromethyl)benzenethiol (1.12 g, 6.31 mmol), 60% sodium hydride in mineral oil (252 mg, 6.31 mmol) and 2-chloro-4-nitropyridine (1.00 g, 12.6 mmol) were reacted to provide 2-chloro-4-(2-(trifluoromethyl)phenylthio)pyridine (1.70 g, 93% yield) as an oil. 1H NMR (CDCl3) δ 8.13 (d, 1H), 7.88 (m, 1H), 7.61-7.72 (m, 4H), 6.85 (s, 1H), 6.80 (m, 1H).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-91402cb62ff64928a6fb9f0815abd529
Source dataset
uspto-grants-2011_09
Patent number
US08022222B2

Reaction notes

Loading…