Methyl 3-mercaptopropionate → HCID 24826835, compound

HRID 911039Notes

Reaction equation

HRID 911039 reaction equation
Br[C:2]1[C:3]([O:15][C:16]2[C:21]([F:22])=[CH:20][CH:19]=[CH:18][C:17]=2[F:23])=[CH:4][C:5]([NH:8][C:9]2[S:10][CH:11]=[C:12]([CH3:14])[N:13]=2)=[N:6][CH:7]=1.C1(P(C2C=CC=CC=2)C2C3OC4C(=CC=CC=4P(C4C=CC=CC=4)C4C=CC=CC=4)C(C)(C)C=3C=CC=2)C=CC=CC=1.[CH3:66][O:67][C:68](=[O:72])[CH2:69][CH2:70][SH:71].C(N(C(C)C)C(C)C)C>C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd].O1CCOCC1>[F:23][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]([F:22])[C:16]=1[O:15][C:3]1[CH:4]=[C:5]([NH:8][C:9]2[S:10][CH:11]=[C:12]([CH3:14])[N:13]=2)[N:6]=[CH:7][C:2]=1[S:71][CH2:70][CH2:69][C:68]([O:67][CH3:66])=[O:72]

Participants

7

Reactant 4

HCID 18050Methyl 3-mercaptopropionateHCID 81531DiisopropylethylamineHCID 6360441,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)HCID 24826754HCID 24826754, compound

Product 1

HCID 24826835HCID 24826835, compoundYield 34.1%

Reagents, catalysts & solvents 2

HCID 9811564Bis(dibenzylideneacetone)palladiumCatalystHCID 312751,4-DioxaneSolvent

Procedure

Tris(dibenzylideneacetone)dipalladium (0) (0.05749 g, 0.06278 mmol), 5-bromo-4-(2,6-difluorophenoxy)-N-(4-methylthiazol-2-yl)pyridin-2-amine (Example 128; 1.0 g, 2.511 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethyl-9H-xanthene (0.07265 g, 0.1256 mmol), methyl-3-mercaptopropanoate (0.2920 ml, 2.637 mmol), N-ethyl-N-isopropylpropan-2-amine (0.8748 ml, 5.022 mmol) and dioxane (50 mL) were heated under argon at 80° C. overnight and then concentrated. The residue was purified by column chromatography to provide the desired product (0.375 g, 33.79% yield) as a yellow solid. 1H NMR (CDCl3) δ 10.97 (s, 1H), 8.37 (s, 1H), 7.26 (m, 1H), 7.03 (t, 2H), 6.26 (s, 1H), 6.03 (s, 1H), 3.67 (s, 3H), 3.12 (t, 2H), 2.62 (t, 2H), 2.06 (s, 3H).

Workup

  1. concentrationconcentrated
  2. customThe residue was purified by column chromatography

Sources & evidence

ORD record
ord-353582f19df44e3cb21e68221c81f9b9
Source dataset
uspto-grants-2011_09
Patent number
US08022222B2

Reaction notes

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