Vinyl Acetate → HCID 19809220, compound

HRID 911457Notes

Reaction equation

HRID 911457 reaction equation
[Br:1][CH2:2][CH2:3][CH2:4][C:5]([OH:7])=[O:6].[C:8](OC=C)(=O)[CH3:9]>C([O-])(=O)C.[Pd+2].C([O-])(=O)C>[CH:8]([O:6][C:5](=[O:7])[CH2:4][CH2:3][CH2:2][Br:1])=[CH2:9]

Participants

4

Reactant 2

HCID 7904Vinyl AcetateHCID 758094-Bromobutyric acid

Product 1

HCID 19809220HCID 19809220, compound

Reagents, catalysts & solvents 1

HCID 167845palladium(II) acetateCatalyst

Procedure

To 4-bromobutyric acid (1.0 g, 6.0 mmol) in vinyl acetate (54 mL) add with stirring palladium(II) acetate (188 mg, 0.84 mmol) and continue stirring overnight at ambient temperature. Filter and concentrate in vacuo to provide the crude desired intermediate.

Workup

  1. filtrationFilter
  2. concentrationconcentrate in vacuo

Sources & evidence

ORD record
ord-c01875a808384d229c67590cfc2f0787
Source dataset
uspto-grants-2011_09
Patent number
US08022062B2

Reaction notes

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