Hydrochloric Acid → HCID 57812685, compound

HRID 911993Notes

Reaction equation

HRID 911993 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH:18]=[C:17]([C:19]3[C:23]4[CH:24]=[N:25][C:26]([NH2:40])=[C:27]([O:28][C@@H:29]([C:31]5[C:36]([Cl:37])=[CH:35][CH:34]=[C:33]([F:38])[C:32]=5[Cl:39])[CH3:30])[C:22]=4[O:21][C:20]=3[Br:41])[CH:16]=[N:15]2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>C(Cl)Cl.C(OCC)C>[Br:41][C:20]1[O:21][C:22]2[C:27]([O:28][C@@H:29]([C:31]3[C:36]([Cl:37])=[CH:35][CH:34]=[C:33]([F:38])[C:32]=3[Cl:39])[CH3:30])=[C:26]([NH2:40])[N:25]=[CH:24][C:23]=2[C:19]=1[C:17]1[CH:16]=[N:15][N:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[CH:18]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57812632HCID 57812632, compound

Product 1

HCID 57812685HCID 57812685, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

To a solution of 4-(4-{6-amino-2-bromo-7-[(R)-1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-furo[3,2-c]pyridin-3-yl}-pyrazol-1-yl)-piperidine-1-carboxylic acid tert-butyl ester (2.0 mg, 0.0030 mmol) in DCM (0.1 mL) was added 1N HCl in diethyl ether (0.2 mL). The resulting mixture was stirred at rt overnight. Evaporation afforded the title compound as a light-yellow gum. LC-MS (ES+): 567.97/569.97/571.99 [MH+].

Workup

  1. customEvaporation

Sources & evidence

ORD record
ord-1dee32a3aac74c4186378b730e539c41
Source dataset
uspto-grants-2011_09
Patent number
US08022206B2

Reaction notes

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