Hydrochloric Acid → HCID 57812300, compound

HRID 911997Notes

Reaction equation

HRID 911997 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]([C:17]2[C:21]3[CH:22]=[N:23][C:24]([NH2:38])=[C:25]([O:26][C@@H:27]([C:29]4[C:34]([Cl:35])=[CH:33][CH:32]=[C:31]([F:36])[C:30]=4[Cl:37])[CH3:28])[C:20]=3[O:19][CH:18]=2)=[O:16])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>C(Cl)Cl.CCOCC>[NH:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]([C:17]2[C:21]3[CH:22]=[N:23][C:24]([NH2:38])=[C:25]([O:26][C@@H:27]([C:29]4[C:34]([Cl:35])=[CH:33][CH:32]=[C:31]([F:36])[C:30]=4[Cl:37])[CH3:28])[C:20]=3[O:19][CH:18]=2)=[O:16])[CH2:10][CH2:9]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57812667HCID 57812667, compound

Product 1

HCID 57812300HCID 57812300, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

To a solution of 4-({6-amino-7-[(R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]furo[3,2-c]pyridine-3-carbonyl}-amino)-piperidine-1-carboxylic acid tert-butyl ester (6.0 mg, 0.01 mmol) in DCM (0.2 mL) was added 1M HCl in Et2O (0.5 mL). The resulting mixture was stirred at rt overnight. LC-MS showed the reaction was complete and gave the desired product. Evaporation under reduced gave the title compound as a white solid. LC-MS (ES+): 467.00/469.04 [MH+].

Sources & evidence

ORD record
ord-d291fa0223ad491099dca25535af4783
Source dataset
uspto-grants-2011_09
Patent number
US08022206B2

Reaction notes

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