反应详情

温度

135 °C

4-Amino-2-chloropyridine (180 mg, 1.4 mmol) was dissolved in 1-methylpiperazine (1 ml), followed by heating at 135° C. for 16 hours in a pressure vessel. After cooling to room temperature, methanol (2 ml) and diethyl ether (2 ml) were added, and the deposited precipitate was filtered off. The resulting solid was washed with cooled diethyl ether followed by drying, to obtain a colorless crystal powder (50 mg, 18.6% yield).

1. temperatureAfter cooling to room temperature
2. filtrationthe deposited precipitate was filtered off
3. washThe resulting solid was washed with cooled diethyl ether
4. customby drying