Boronic Acid → HCID 24890443, compound

HRID 912137Notes

Reaction equation

HRID 912137 reaction equation
Cl[C:2]1[C:3]2[CH2:16][CH2:15][N:14]([C:17]3[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=3)[C:4]=2[N:5]=[C:6]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[N:7]=1.[CH3:23][O:24][C:25]1[N:30]=[CH:29][C:28](B(O)O)=[CH:27][N:26]=1.B(O)O>>[CH3:23][O:24][C:25]1[N:30]=[CH:29][C:28]([C:2]2[C:3]3[CH2:16][CH2:15][N:14]([C:17]4[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=4)[C:4]=3[N:5]=[C:6]([N:8]3[CH2:13][CH2:12][O:11][CH2:10][CH2:9]3)[N:7]=2)=[CH:27][N:26]=1

Participants

4

Reactant 3

HCID 61668Boronic AcidHCID 27367782-Methoxypyrimidine-5-boronic acidHCID 592447084-chloro-2-morpholin-4-yl-7-pyridin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

Product 1

HCID 24890443HCID 24890443, compound

Procedure

In the same manner as Example 1-B-10, using 4-chloro-2-morpholin-4-yl-7-pyridin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine, and 2-methoxypyrimidin-5-boronic acid as a boronic acid, 4-(2-methoxy-pyrimidin-5-yl)-2-morpholin-4-yl-7-pyridin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine was obtained. This was demethylated in the same manner as Example 1-B-42, to obtain the desired compound.

Sources & evidence

ORD record
ord-8f36eea9c4824ea19f5d72636084da46
Source dataset
uspto-grants-2011_09
Patent number
US08022205B2

Reaction notes

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