Trifluoroacetic acid → HCID 24888238, compound

HRID 912143Notes

Reaction equation

HRID 912143 reaction equation
C([O:5][C:6]1[CH:7]=[C:8]([C:12]2[C:13]3[CH2:26][CH2:25][N:24]([CH:27]=[O:28])[C:14]=3[N:15]=[C:16]([N:18]3[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)[N:17]=2)[CH:9]=[CH:10][CH:11]=1)(C)(C)C.FC(F)(F)C(O)=O>>[OH:5][C:6]1[CH:7]=[C:8]([C:12]2[C:13]3[CH2:26][CH2:25][N:24]([CH:27]=[O:28])[C:14]=3[N:15]=[C:16]([N:18]3[CH2:19][CH2:20][O:21][CH2:22][CH2:23]3)[N:17]=2)[CH:9]=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86640121HCID 86640121, compound

Product 1

HCID 24888238HCID 24888238, compoundYield 47%

Procedure

4-(3-t-Butoxy-phenyl)-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-carbaldehyde (5 mg) obtained from Example 1-C-07 as a byproduct was treated with trifluoroacetic acid (1 ml), and the solvent was distilled off, which was subsequently diluted with water (1 ml), and extracted with dichloromethane (3 ml×3), followed by concentration under reduced pressure, to obtain a colorless powder (2 mg, 47%).

Workup

  1. distillationthe solvent was distilled off
  2. additionwhich was subsequently diluted with water (1 ml)
  3. extractionextracted with dichloromethane (3 ml×3)
  4. concentrationfollowed by concentration under reduced pressure

Sources & evidence

ORD record
ord-4191640670044e20b1be3e7df69b15d2
Source dataset
uspto-grants-2011_09
Patent number
US08022205B2

Reaction notes

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