4-Nitrobenzoic Acid → (4-Methylpiperazin-1-yl)(4-nitrophenyl)methanone

HRID 912321Notes

Reaction equation

HRID 912321 reaction equation
[N+:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=O)=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH3:13][N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>>[CH3:13][N:14]1[CH2:19][CH2:18][N:17]([C:8]([C:7]2[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:12][CH:11]=2)=[O:10])[CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 61084-Nitrobenzoic AcidHCID 531671-Methylpiperazine

Product 1

HCID 716396(4-Methylpiperazin-1-yl)(4-nitrophenyl)methanone

Procedure

Using 4-nitro-benzoic acid (1 g) instead of 3-nitro-benzoic acid, and 1-methyl-piperazine (797 μl) instead of 1-ethyl-piperazine, in the same manner as Step A in Example 1-D-101, the desired compound was obtained as a crude product.

Sources & evidence

ORD record
ord-e3c7ed43b1a44dff9dd04794aa9cdd7e
Source dataset
uspto-grants-2011_09
Patent number
US08022205B2

Reaction notes

Loading…