Ammonia → HCID 62846302, compound

HRID 912686Notes

Reaction equation

HRID 912686 reaction equation
[NH2:1][CH2:2][C:3]1[CH:8]=[N:7][C:6]([CH3:9])=[CH:5][N:4]=1.C([N:18]=[C:19]=[S:20])(=O)C1C=CC=CC=1.N>CO>[CH3:9][C:6]1[N:7]=[CH:8][C:3]([CH2:2][NH:1][C:19]([NH2:18])=[S:20])=[N:4][CH:5]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 68284Benzoyl isothiocyanateHCID 27564962-(Aminomethyl)-5-methylpyrazine

Product 1

HCID 62846302HCID 62846302, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound was prepared in accordance with the general method described in Example 12(a) by using 2-(aminomethyl)-5-methylpyrazine (1.00 g, 7.89 mmol), benzoyl isothiocyanate (1.20 mL, 8.90 mmol) and ammonia in methanol (7 N, 27 mL) with the exception that the crude product isolated by filtration (1.30 g, 91% yield) was used in the next step without further purification.

Workup

  1. customisolated by filtration (1.30 g, 91% yield)
  2. customwas used in the next step without further purification

Sources & evidence

ORD record
ord-ae90332c31d94c9a8d95bbdf234d9601
Source dataset
uspto-grants-2011_09
Patent number
US08026244B2

Reaction notes

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