Ammonia → HCID 86631134, compound

HRID 912693Notes

Reaction equation

HRID 912693 reaction equation
[CH3:1][C:2]1[C:3]([CH2:7][NH2:8])=[N:4][O:5][N:6]=1.C([N:17]=[C:18]=[S:19])(=O)C1C=CC=CC=1.N>CO>[CH3:1][C:2]1[C:3]([CH2:7][NH:8][C:18]([NH2:17])=[S:19])=[N:4][O:5][N:6]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 68284Benzoyl isothiocyanateHCID 5658614-Methyl-furazan-3-ylmethylamine HCl

Product 1

HCID 86631134HCID 86631134, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound was prepared in accordance with the general method described in Example 12(a) by using 1-(4-methyl-1,2,5-oxadiazol-3-yl)methylamine (0.46 g, 4.1 mmol), benzoyl isothiocyanate (0.60 mL, 4.5 mmol) and ammonia in methanol (7 N, 25 mL) with the exception that the crude product isolated by filtration (0.55 g, 78% yield) was used in the next step without further purification.

Workup

  1. customisolated by filtration (0.55 g, 78% yield)
  2. customwas used in the next step without further purification

Sources & evidence

ORD record
ord-d3d3b0236bf34d28985288871a35cc95
Source dataset
uspto-grants-2011_09
Patent number
US08026244B2

Reaction notes

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