Ethyl cyanoacetate → HCID 86631135, compound

HRID 912694Notes

Reaction equation

HRID 912694 reaction equation
[CH3:1][C:2]1[C:3]([CH2:7][NH:8][C:9]([NH2:11])=[S:10])=[N:4][O:5][N:6]=1.[O-]CC.[Na+].[C:16]([CH2:18][C:19](OCC)=[O:20])#[N:17]>>[NH2:17][C:16]1[N:8]([CH2:7][C:3]2[C:2]([CH3:1])=[N:6][O:5][N:4]=2)[C:9](=[S:10])[NH:11][C:19](=[O:20])[CH:18]=1

Participants

4

Reactant 3

HCID 7764Ethyl cyanoacetateHCID 2723922Sodium ethoxideHCID 86631134HCID 86631134, compound

Product 1

HCID 86631135HCID 86631135, compoundYield 58%

Procedure

The title compound was prepared in accordance with the general method described in Example 12(b) by using 1-[(4-methyl-1,2,5-oxadiazol-3-yl)methyl]thiourea (0.55 g, 3.2 mmol, obtained from Example 16(a)), sodium ethoxide (21% w/v, 3.1 mL, 9.5 mmol) and ethyl cyanoacetate (1.0 mL, 9.5 mmol) which provided the title compound (0.44 g, 58% yield).

Workup

  1. customThe title compound was prepared in accordance with the general method

Sources & evidence

ORD record
ord-bca56a5d3dda4f04882bb5206987f75c
Source dataset
uspto-grants-2011_09
Patent number
US08026244B2

Reaction notes

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