Hydrochloric Acid → (2-Chloro-pyridin-4-yl)-(4,5-difluoro-2,3-dihydro-indol-1-yl)-methanone

HRID 91278Notes

Reaction equation

HRID 91278 reaction equation
[B-:23]([F:24])([F:25])([F:26])[F:27].[C:45](=[O:46])([O-:47])[O-:48].[Cl:1][c:2]1[cH:3][c:4]([C:5](=[O:6])[OH:7])[cH:8][cH:9][n:10]1.[ClH:11].[F:12][c:13]1[c:14]2[c:18]([cH:19][cH:20][c:21]1[F:22])[NH:17][CH2:16][CH2:15]2.[K+:49].[K+:50].[O:51]=[CH:52][N:53]([CH3:54])[CH3:55].[n:28]1([O:29][C:30]([N:31]([CH3:32])[CH3:33])=[N+:34]([CH3:35])[CH3:36])[c:37]2[cH:38][cH:39][cH:40][cH:41][c:42]2[n:43][n:44]1>>[Cl:1][c:2]1[cH:3][c:4]([C:5](=[O:7])[N:17]2[CH2:16][CH2:15][c:14]3[c:13]([F:12])[c:21]([F:22])[cH:20][cH:19][c:18]32)[cH:8][cH:9][n:10]1

Participants

9

Reactant 8

HCID 313Hydrochloric AcidHCID 813Potassium Cation2×HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 26255TetrafluoroborateHCID 130500O-benzotriazol-1-yl-tetramethyluroniumHCID 2369852-Chloroisonicotinic acidHCID 441823444,5-Difluoroindoline

Product 1

HCID 58117528(2-Chloro-pyridin-4-yl)-(4,5-difluoro-2,3-dihydro-indol-1-yl)-methanone

Sources & evidence

ORD record
ord-781e7657c39143c7ba0f707e22030ed0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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