HRID912912

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8082

Piperidine

C5H11N

结构：C[Si](C)(C)CCOCn1c(N2CCN(c3ncccc3C(F)(F)F)CC2)nc2c(Br)cc(C(F)(F)F)cc21

HCID11520127

未命名化合物

PRODUCTS

生成物

结构：C[Si](C)(C)CCOCn1c(N2CCN(c3ncccc3C(F)(F)F)CC2)nc2c(N3CCCCC3)cc(C(F)(F)F)cc21

HCID11541868

未命名化合物

PROCEDURE

实验过程

4-Bromo-6-trifluoromethyl-2-[4-(3-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzoimidazole from step (a) above (160 mg, 0.26 mmol) and piperidine (84 mg, 1 mmol) reacted under the conditions of Example 127b to give the title compound as an oil. MS (ESI, pos. ion) m/z: 629 (M+1).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8ea3efb1a7db44cf99a8d99a848dbf74
来源数据集: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08026241B2
来源说明: uspto-grants-2011_09

反应 SMILES

Br[C:2]1[C:10]2[N:9]=[C:8]([N:11]3[CH2:16][CH2:15][N:14]([C:17]4[C:22]([C:23]([F:26])([F:25])[F:24])=[CH:21][CH:20]=[CH:19][N:18]=4)[CH2:13][CH2:12]3)[N:7]([CH2:27][O:28][CH2:29][CH2:30][Si:31]([CH3:34])([CH3:33])[CH3:32])[C:6]=2[CH:5]=[C:4]([C:35]([F:38])([F:37])[F:36])[CH:3]=1.[NH:39]1[CH2:44][CH2:43][CH2:42][CH2:41][CH2:40]1>>[N:39]1([C:2]2[C:10]3[N:9]=[C:8]([N:11]4[CH2:16][CH2:15][N:14]([C:17]5[C:22]([C:23]([F:26])([F:25])[F:24])=[CH:21][CH:20]=[CH:19][N:18]=5)[CH2:13][CH2:12]4)[N:7]([CH2:27][O:28][CH2:29][CH2:30][Si:31]([CH3:34])([CH3:33])[CH3:32])[C:6]=3[CH:5]=[C:4]([C:35]([F:38])([F:37])[F:36])[CH:3]=2)[CH2:44][CH2:43][CH2:42][CH2:41][CH2:40]1