反应详情

温度

10 °C

Sodium hydride (17.8 g, 445 mmol) was added portionwise to a solution of benzyl ethyl malonate (98.9, 445 mmol) in dry DMF (280 ml) and stirred for 10 minutes. Cooled to 10° C. over 30 minutes. 2,4-difluoro-1-nitrobenzene (48.9 ml, 445 mmol) was added and stirred at room temperature for 16 hours. The reaction mixture was quenched with 2N hydrochloric acid (150 ml) to pH 3-4 then extracted ×2 with ether. The combined organics washed with 2× water and brine, dried over magnesium sulphate and evaporated to a yellow oil. Purified by chromatography on silica gel eluting with 5% ethyl acetate in hexane to give the title compound as a yellow oil (11.66, 32.3 mmol). LC/MS: Rt=3.39, [MH]− 360.

1. stirringstirred at room temperature for 16 hours
2. customThe reaction mixture was quenched with 2N hydrochloric acid (150 ml) to pH 3-4
3. extractionthen extracted ×2 with ether
4. washThe combined organics washed with 2× water and brine
5. dry with materialdried over magnesium sulphate
6. customevaporated to a yellow oil
7. customPurified by chromatography on silica gel eluting with 5% ethyl acetate in hexane