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HRID913531

反应详情

EQUATION

反应方程式

HRID 913531 的结构方程式

REACTANTS

反应物

5
结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：CCN=C=NCCCN(C)C.Cl
HCID2723939

1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride

C8H18ClN3

结构：CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F
HCID9886157

Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

C10H15F6N6OP

结构：Cc1cc2c(C(F)(F)F)c(C#N)ccc2n1C(C)(C)C(=O)O
HCID57800504

未命名化合物

结构：N=C(NO)c1ccc(F)cc1
HCID178513323

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cc2c(C(F)(F)F)c(C#N)ccc2n1C(C)(C)c1nc(-c2ccc(F)cc2)no1
HCID57800311

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC#N
溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

Synthesized as described in Example 37 from 2-[5-cyano-2-methyl-4-(trifluoromethyl)-1H-indol-1-yl]-2-methylpropanoic acid and 4-fluoro-N-hydroxybenzenecarboximidamide using MeCN as the solvent, and HATU (1.05 eq), DIEA (1.05 eq), instead of EDCl, for the first coupling step: MS (ES) m/z 429 (M+1).

WORKUP

后处理

  1. customSynthesized