反应详情

2-Mercapto-4-(3-phthalimidopropyl)-1,3-thiazole (22.6 g) obtained in Example 31 was dissolved in N,N-dimethylformamide (200 mL), potassium carbonate (11.3 g) and 2-bromo-2-methylpropionic acid tert-butyl ester (17.4 g) were added, and the mixture was stirred at room temperature for 14 hr. The reaction mixture was concentrated under reduced pressure, ethyl acetate and water were added, and the mixture was stirred. The organic layer was dried over magnesium sulfate and evaporated under reduced pressure. The residue was purified by silica gel chromatography (elution solvent; hexane:ethyl acetate=7:3) to give the title compound (32.0 g) as a colorless oil.

1. concentrationThe reaction mixture was concentrated under reduced pressure, ethyl acetate and water
2. additionwere added
3. stirringthe mixture was stirred
4. dry with materialThe organic layer was dried over magnesium sulfate
5. customevaporated under reduced pressure
6. customThe residue was purified by silica gel chromatography (elution solvent; hexane:ethyl acetate=7:3)