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HRID9143

反应详情

EQUATION

反应方程式

HRID 9143 的结构方程式

REACTANTS

反应物

3
结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：O=C(Cl)c1cc(F)ccc1F
HCID588082

2,5-Difluorobenzoyl chloride

C7H3ClF2O

结构：CCNC(=O)Nc1nc2ccc(C(=O)CCN)cc2s1
HCID21985556

未命名化合物

PRODUCTS

生成物

1
结构：CCNC(=O)Nc1nc2ccc(C(=O)CCNC(=O)c3cc(F)ccc3F)cc2s1
HCID21985558

未命名化合物

收率 22%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Similar to the synthesis of Example 249, a mixture of 1-(6-(3-aminopropanoyl)-2-benzothiazolyl)-3-ethylurea, triethylamine and 2,5-difluorobenzoyl chloride in DMF was reacted to give the desired compound 0.019 g (22%). LC/MS 433.0 (M+1); LC retention time 2.94 min.

WORKUP

后处理

  1. customSimilar to the synthesis of Example 249
  2. customwas reacted