Trifluoroacetic acid → HCID 67398811, compound

HRID 914429Notes

Reaction equation

HRID 914429 reaction equation
C([O:5][C:6](=[O:20])[C:7]([S:10][C:11]1[S:12][CH:13]=[C:14]([CH2:16][C:17](O)=O)[N:15]=1)([CH3:9])[CH3:8])(C)(C)C.[NH2:21][C:22]1[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=1.[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31]>ClCCl>[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31].[CH2:23]([N:21]([C:22]1[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=1)[CH2:17][CH2:16][C:14]1[N:15]=[C:11]([S:10][C:7]([CH3:8])([CH3:9])[C:6]([OH:5])=[O:20])[S:12][CH:13]=1)[CH2:22][CH2:27][CH2:26][CH2:25][CH2:29][CH3:30]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 100093-AminopyridineHCID 59759443{2-[(2-Tert-butoxy-1,1-dimethyl-2-oxoethyl)thio]-1,3-thiazol-4-yl}acetic acid

Product 1

HCID 67398811HCID 67398811, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A compound obtained using {2-[(2-tert-butoxy-1,1-dimethyl-2-oxoethyl)thio]-1,3-thiazol-4-yl}acetic acid synthesized in Example 3 and 3-aminopyridine as starting materials and by an operation similar to that of Example 293-1 was treated with dichloromethane and trifluoroacetic acid, and the mixture was stirred at room temperature for 12 hr. The reaction solution was concentrated under reduced pressure, azeotroped with diethyl ether, and the precipitated solid was collected by filtration to give the title compound.

Workup

  1. customA compound obtained
  2. concentrationThe reaction solution was concentrated under reduced pressure
  3. customazeotroped with diethyl ether
  4. filtrationthe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-f2b56a150cb1403288e7333f852cdc80
Source dataset
uspto-grants-2011_09
Patent number
US08026370B2

Reaction notes

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